MetaMorph 7.6

Molecular Devices provides high quality, cost effective and fully supported imaging systems through custom integration of hardware devices with MetaMorph software.

The MetaMorphosis continues! MetaMorph 7.6 is the next generation of world-class image acquisition and analysis software from Molecular Devices. MetaMorph 7.6 now includes two new applications; 3D Track Objects and the Micronuclei Application Module. Also, we increased our supported hardware with OptiGrid SIM and automated slide handling plus much more. We also added new functionality to multidimensional acquisition and analysis.

Combining the most flexible and powerful tools for image acquisition, processing, and analysis, MetaMorph imaging systems offer a complete solution for even the most demanding live-cell imaging needs.

New Features

MetaMorph® Software now supports the OptiGrid® from Qioptiq

The OptiGrid is now fully controlled using MetaMorph software via a USB connection, which ensures simple system integration. Utilizing the light emitted from an existing stabilized illumination source, the OptiGrid uses a one-dimensional optical grid mounted on a piezo-electronically driven actuator to project a line pattern onto the specimen. The grid is then moved perpendicularly to the grid lines, in 1/3 steps of its period length so that three grid movements result in one optical section.

The structured illumination process returns a strong signal wherever focus is sharp and a weak signal where focus is soft. Furthermore, a patented algorithm is used to combine these strong signals from the grid images so that each optical section contains data that is exactly within the focal plane. A series of optical sections taken through a sample (z-stack) can then be combined to create a haze-free ultra-sharp composite image. Image stacks can also be used to produce 3D reconstructions using post processing software.

The OptiGrid slider is inserted into the field diaphragm slot of a standard illuminator on upright or inverted microscopes. This enables it to be used with any of the wavelengths available from the illumination system from UV to IR and also to be easily removed for standard microscope functions. Furthermore, it provides users with excellent imaging throughput and programmable experiment repeatability for parallel multiple-specimen imaging.

The OptiGrid is an excellent and cost efficient system for expanding the imaging capabilities of new or existing microscopes without taking up valuable laboratory space. Offering confocal-like image quality, the OptiGrid integrates quickly and easily with many microscopes.

MetaMorph® Software now supports Slide Handler from Ludl Electronic Products

Simplicity, flexibility, affordability, reliability: these are the design criteria for the LEP slide handler system. Along with MetaMorph, the resulting system goes beyond these criteria by offering an easily expandable system that provides a complete solution for microscope automation.

The simplicity of the slide transfer mechanism provides efficient, reliable slide loading. A single arm functions to pull the slide from the cassette to the stage and then return it with an opposite pushing motion. Once the slide is transferred to the stage it is located with a unique fixturing device for repeatable positioning and slide reloading in all axes. As the precision XY stage scans the slide, the transfer mechanism is completely clear of any interference with normal microscope function.

Flexibility is guaranteed by the random access capability. Cassettes are configurable as input only, output only or input/output depending upon your specific requirements. This makes the system ideally suited for high volume screening, analysis, classification and review applications.

Applications

In the progressive field of imaging, system versatility is of foremost importance. MetaMorph offers tailored solutions for a full range of applications:

3D deconvolution 3D reconstruction Angiogenesis/ Endothelial tube formation Brightness measurements Cell counting Cell cycle Cell migration Cell proliferation Cell viability Colocalization Cytotoxicity and apoptosis Deconvolution Densitometry Fluorescence overlay Fluorescence in situ hybridization (FISH) Fluorescence immunocytochemistry Fluorescence Recovery after Photobleaching (FRAP)

Fluorescence Resonance Energy Transfer (FRET) Fluorescence Live/Dead Morphometry Motion analysis & particle tracking Mitosis Monopole detection Multi-dimensional imaging Neurite outgrowth/ process extension Ratio and calcium imaging Receptor internalization Stitching Time lapse Tissue imaging Volume measurements Z series

Sales

To find your local Meta Imaging Series Sales Specialist, visit our Distributors page.

Support

For support options, please visit our Meta Imaging Series Support page.